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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIRA
All Species:
17.27
Human Site:
T586
Identified Species:
23.75
UniProt:
P54198
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54198
NP_003316.3
1017
111835
T586
A
P
A
L
T
S
M
T
P
T
A
V
E
R
L
Chimpanzee
Pan troglodytes
XP_001165585
1017
111787
T586
A
P
A
L
T
S
M
T
P
T
A
V
E
R
L
Rhesus Macaque
Macaca mulatta
XP_001112873
1138
124408
T707
A
P
A
L
T
S
V
T
P
T
A
A
E
R
L
Dog
Lupus familis
XP_543550
1017
111618
T586
A
P
A
L
T
S
V
T
P
T
A
M
E
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61666
1015
111748
P586
P
S
L
T
S
V
I
P
T
A
V
E
R
L
K
Rat
Rattus norvegicus
NP_001129232
1015
111665
P586
P
S
L
T
S
V
I
P
T
A
V
E
R
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P79987
1019
112055
A586
S
K
A
T
S
G
T
A
V
V
T
N
T
N
Q
Frog
Xenopus laevis
Q8QFR2
1013
112021
T586
G
V
A
H
L
N
Q
T
A
V
D
R
L
K
E
Zebra Danio
Brachydanio rerio
XP_696478
1010
111223
D586
T
I
G
I
T
P
L
D
R
A
K
D
S
S
S
Tiger Blowfish
Takifugu rubipres
O42611
1025
111838
P586
A
S
S
T
G
L
T
P
S
E
R
P
K
E
S
Fruit Fly
Dros. melanogaster
O17468
1047
113397
A583
K
T
Q
H
G
M
L
A
K
V
T
A
S
D
S
Honey Bee
Apis mellifera
XP_001122939
838
91355
T432
N
K
Q
I
E
T
R
T
S
D
G
K
R
R
I
Nematode Worm
Caenorhab. elegans
Q09589
935
103412
D529
E
D
S
S
D
S
D
D
D
D
E
E
E
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q32SG6
964
105548
L558
R
A
N
I
T
E
S
L
V
I
Q
K
A
S
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LXN4
1051
115544
D586
I
K
E
S
S
S
T
D
L
L
I
R
V
F
D
Baker's Yeast
Sacchar. cerevisiae
P32479
840
93871
T434
Q
T
K
S
F
K
H
T
K
I
S
T
S
K
L
Red Bread Mold
Neurospora crassa
Q7RZI0
1035
112420
P584
R
S
A
T
G
P
V
P
I
V
V
N
G
V
E
Conservation
Percent
Protein Identity:
100
99.9
88.4
96.5
N.A.
95.7
95.5
N.A.
N.A.
86
78
69.8
67.7
31.1
40
26.5
N.A.
Protein Similarity:
100
99.9
88.9
98
N.A.
97.5
97.7
N.A.
N.A.
93.1
88.5
83.2
81.3
48
55.1
46.1
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
0
0
N.A.
N.A.
6.6
13.3
6.6
6.6
0
13.3
13.3
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
13.3
13.3
N.A.
N.A.
20
26.6
20
20
6.6
33.3
20
N.A.
Percent
Protein Identity:
N.A.
25.6
N.A.
25
22.4
25.9
Protein Similarity:
N.A.
43.7
N.A.
43.3
41.2
45.8
P-Site Identity:
N.A.
6.6
N.A.
6.6
13.3
6.6
P-Site Similarity:
N.A.
13.3
N.A.
13.3
26.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
6
42
0
0
0
0
12
6
18
24
12
6
0
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
0
0
6
0
6
18
6
12
6
6
0
6
6
% D
% Glu:
6
0
6
0
6
6
0
0
0
6
6
18
30
12
18
% E
% Phe:
0
0
0
0
6
0
0
0
0
0
0
0
0
6
0
% F
% Gly:
6
0
6
0
18
6
0
0
0
0
6
0
6
0
0
% G
% His:
0
0
0
12
0
0
6
0
0
0
0
0
0
0
0
% H
% Ile:
6
6
0
18
0
0
12
0
6
12
6
0
0
0
6
% I
% Lys:
6
18
6
0
0
6
0
0
12
0
6
12
6
12
12
% K
% Leu:
0
0
12
24
6
6
12
6
6
6
0
0
6
12
30
% L
% Met:
0
0
0
0
0
6
12
0
0
0
0
6
0
0
0
% M
% Asn:
6
0
6
0
0
6
0
0
0
0
0
12
0
6
0
% N
% Pro:
12
24
0
0
0
12
0
24
24
0
0
6
0
0
0
% P
% Gln:
6
0
12
0
0
0
6
0
0
0
6
0
0
0
6
% Q
% Arg:
12
0
0
0
0
0
6
0
6
0
6
12
18
30
0
% R
% Ser:
6
24
12
18
24
36
6
0
12
0
6
0
18
12
18
% S
% Thr:
6
12
0
30
36
6
18
42
12
24
12
6
6
0
0
% T
% Val:
0
6
0
0
0
12
18
0
12
24
18
12
6
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _